CHRNA5 – Neuronal acetylcholine receptor subunit alpha-5


Names and origin

Protein names Recommended name:
Neuronal acetylcholine receptor subunit alpha-5
Gene names
Name: CHRNA5
Synonyms: NACHRA5
Organism Homo sapiens (Human) [Complete proteome]
Taxonomic identifier 9606 [NCBI]
Taxonomic lineage Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length 468 AA.
Sequence status Complete.
Sequence processing The displayed sequence is further processed into a mature form.
Protein existence Evidence at transcript level.

General annotation (Comments)

Function After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subunit structure Neuronal AChR seems to be composed of two different type of subunits: alpha and non-alpha (beta).
Subcellular location Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Polymorphism Genetic variations in CHRNA5 have been associated with susceptibility to smoking-related behavioral traits and lung cancer, contributing to the smoking quantitative trait locus 3 (SQTL3) [MIM:612052].
Sequence similarities Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-5/CHRNA5 sub-subfamily. [View classification]

Ontologies

Keywords
Biological process Ion transport
Transport
Cellular component Cell junction
Cell membrane
Membrane
Postsynaptic cell membrane
Synapse
Coding sequence diversity Polymorphism
Domain Signal
Transmembrane
Transmembrane helix
Molecular function Ionic channel
Ligand-gated ion channel
Receptor
PTM Disulfide bond
Glycoprotein
Technical term Complete proteome
Gene Ontology (GO)
Biological process behavioral response to nicotineInferred from mutant phenotype. Source: UniProtKB
Cellular component cell junctionInferred from electronic annotation. Source: UniProtKB-KW 

nicotinic acetylcholine-gated receptor-channel complexInferred by curator Ref.1. Source: UniProtKB

postsynaptic membraneInferred from electronic annotation. Source: UniProtKB-SubCell

Molecular function acetylcholine receptor activityInferred from direct assay Ref.1. Source: UniProtKB 

nicotinic acetylcholine-activated cation-selective channel activityNon-traceable author statement Ref.1. Source: UniProtKB

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